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Phosphorylation of eIF4E-BP will affect translation in what way?(a) Increase(b) Decrease(c) No effect(d) There is no such factorI have been asked this question in an internship interview.Question is from Initiation topic in portion Gene Expression : Translation of Cytogenetics

Answer»

Correct choice is (a) Increase

The best I can explain: EIF4E-BP is the active form of the FACTOR which can bind to the eIF4E and prevent TRANSLATION. When phosphorylated, this BINDING is sterically prevented. Thus, phosphorylation increases translation generating FREE eIF4E.



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