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In the first committed step of pyrimidine biosynthesis, the reaction is catalyzed by ____________(a) Adenylate kinase(b) Aspartate transcarbamoylase(c) Dihyhroorotase(d) Cytidylate synthaseI got this question in an online interview.Question is from Biosynthesis and Degradation of Nucleotides topic in section Lipid Biosynthesis, Biosynthesis of Amino Acids, Nucleotides and Related Molecules of Biochemistry

Answer» CORRECT answer is (b) Aspartate transcarbamoylase

To explain I would say: Carbamoyl PHOSPHATE reacts with aspartate to yield N-carbamoylaspartate in the FIRST COMMITTED STEP of pyrimidine biosynthesis catalyzed by aspartate transcarbamoylase.


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