Local anesthetics increase the axonal Na+ entry.(a) True(b) FalseI had been asked this question in an international level competition.My question is taken from Mechanism of Action of General Anesthetics in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Local anesthetics increase the axonal Na+ entry.(a) True(b) FalseI had

1.	Local anesthetics increase the axonal Na+ entry.(a) True(b) FalseI had been asked this question in an international level competition.My question is taken from Mechanism of Action of General Anesthetics in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology
Answer» Correct choice is (b) False The BEST I can explain: Local ANESTHETICS help block conduction. It decreases the axonal Na+ entry thus prevents action potential PROPAGATION. Administration of general anesthetics decreases the presynaptic Ca^2+ entry, thus decreases the neurotransmitter release. It INCREASES postsynaptic Cl^– entry and ALSO increases postsynaptic K+ leakage from the cell.

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