On the cytoplasmic site of GCPRs, the G-proteins bind to ___________________(a) amino-terminus(b) promoter region(c) second loop(d) third loopI had been asked this question at a job interview.Query is from Cell Signaling and Signal Transduction topic in chapter Cell Signaling and Signal Transduction of Cell Biology

On the cytoplasmic site of GCPRs, the G-proteins bind to _____________

1.	On the cytoplasmic site of GCPRs, the G-proteins bind to ___________________(a) amino-terminus(b) promoter region(c) second loop(d) third loopI had been asked this question at a job interview.Query is from Cell Signaling and Signal Transduction topic in chapter Cell Signaling and Signal Transduction of Cell Biology
Answer» The correct ANSWER is (d) third loop Explanation: There are 3 loops of G-protein coupled receptor located on the outside of the CELL and 3 loops located on the cytoplasmic site. The G-proteins bind to the third INTRACELLULAR loop while the loops located outside the cell FORM the ligand-binding ACTIVE site.

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