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Puromycin is a ribosomal antibiotic. It binds to ________(a) Peptide exit channel(b) 16S rRNA(c) tRNA binding site(d) A site of unassociated 16S rRNAThis question was addressed to me during an internship interview.I'm obligated to ask this question of Ribosome topic in portion Gene Expression : Translation of Cytogenetics

Answer»

The correct option is (c) TRNA BINDING site

For EXPLANATION: Puromycinis a tRNA analogue that has an amide bond in place of ester bond. This is why when the RIBOSOME transfers the PEPTIDE over this; it flees with the peptide and stops the translation.



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