The Cholera toxin produced by Vibrio cholera exerts its effect by _____________________(a) modifying G-protein(b) modifying primary messengers(c) modifying effectors(d) modifying receptorsThis question was posed to me by my school principal while I was bunking the class.The query is from Cell Signaling and Signal Transduction topic in section Cell Signaling and Signal Transduction of Cell Biology

The Cholera toxin produced by Vibrio cholera exerts its effect by ____

1.	The Cholera toxin produced by Vibrio cholera exerts its effect by _____________________(a) modifying G-protein(b) modifying primary messengers(c) modifying effectors(d) modifying receptorsThis question was posed to me by my school principal while I was bunking the class.The query is from Cell Signaling and Signal Transduction topic in section Cell Signaling and Signal Transduction of Cell Biology
Answer» The correct ANSWER is (a) modifying G-protein The best EXPLANATION: The cholera toxin exerts its effect by inhibiting the GTPase ACTIVITY of G-proteins in the CELLS of intestinal epithelium and modifying their G-alpha subunits. This causes the epithelial cells to secrete large volumes of FLUID into the intestinal lumen.

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