The production of casein by rat mammary gland tissue reduces 100 fold in the absence of prolactin hormone. This reduction is due to_____________(a) Binding of eIF4E by PHAS 1(b) Greater turnover of mRNA for casein(c) Lesser synthesis of casein mRNA(d) Development of secondary structure on mRNA preventing translationI got this question during an interview.Query is from Control of Translation in portion Gene Expression : Translation of Cytogenetics

The production of casein by rat mammary gland tissue reduces 100 fold

1.	The production of casein by rat mammary gland tissue reduces 100 fold in the absence of prolactin hormone. This reduction is due to_____________(a) Binding of eIF4E by PHAS 1(b) Greater turnover of mRNA for casein(c) Lesser synthesis of casein mRNA(d) Development of secondary structure on mRNA preventing translationI got this question during an interview.Query is from Control of Translation in portion Gene Expression : Translation of Cytogenetics
Answer» Correct choice is (b) Greater turnover of mRNA for CASEIN The explanation: It has been seen in vitro that treatment with prolactin only INCREASES the PRODUCTION of casein mRNA to 3 fold, but there is an increase of 100 fold in casein level. So, this must be due to an increase in stability by the change in protein turnover RATE.

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