The signal sequence that determines whether a protein will be synthesized on a free ribosome or ribosome attached to endoplasmic reticulum is located at _______(a) N-terminal(b) C-terminal(c) hydrophobic tail(d) hydrophilic tailI had been asked this question during an interview.Asked question is from Cytoplasmic Membrane Systems in chapter Cytoplasmic Membrane Systems of Cell Biology

The signal sequence that determines whether a protein will be synthesi

1.	The signal sequence that determines whether a protein will be synthesized on a free ribosome or ribosome attached to endoplasmic reticulum is located at _______(a) N-terminal(b) C-terminal(c) hydrophobic tail(d) hydrophilic tailI had been asked this question during an interview.Asked question is from Cytoplasmic Membrane Systems in chapter Cytoplasmic Membrane Systems of Cell Biology
Answer» Right choice is (a) N-terminal The explanation is: There are TWO LOCATIONS in a cell where a protein can be synthesized depending UPON its type and function. The signal that directs the SYNTHESIS of a protein to a FREE ribosome or ribosome attached to the endoplasmic reticulum is found in the C-terminal of the protein.

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