Which antibiotic inhibits peptidyl transfer by blocking the accommodation of aa-tRNA into the peptidyl transferase (A/A) site?(a) Chloramphenicol(b) Penicillin(c) Tetracyclin(d) ViomycinI have been asked this question in a job interview.Question is from Ribosome in portion Gene Expression : Translation of Cytogenetics

Which antibiotic inhibits peptidyl transfer by blocking the accommodat

1.	Which antibiotic inhibits peptidyl transfer by blocking the accommodation of aa-tRNA into the peptidyl transferase (A/A) site?(a) Chloramphenicol(b) Penicillin(c) Tetracyclin(d) ViomycinI have been asked this question in a job interview.Question is from Ribosome in portion Gene Expression : Translation of Cytogenetics
Answer» The correct ANSWER is (c) Tetracyclin Explanation: While CHLORAMPHENICOL also BLOCKS the peptidyl transferase ACTIVITY, tetracycline does so by blocking the A site. Then the A site amino acid can’t interact with the P site one for the REACTION to take place.

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