Which of the bases are important in detecting whether the AUG should be the start site for eukaryotic initiation?(a) -2 and +3(b) -4 and +3(c) -3 and +4(d) -1 and +4The question was posed to me in an international level competition.My question is taken from Initiation topic in chapter Gene Expression : Translation of Cytogenetics

Which of the bases are important in detecting whether the AUG should b

1.	Which of the bases are important in detecting whether the AUG should be the start site for eukaryotic initiation?(a) -2 and +3(b) -4 and +3(c) -3 and +4(d) -1 and +4The question was posed to me in an international level competition.My question is taken from Initiation topic in chapter Gene Expression : Translation of Cytogenetics
Answer» Right OPTION is (c) -3 and +4 To explain: The CONSENSUS sequence CC(A/G)CCAUGG was DISCOVERED by Kozak, where the purine in -3 and +4 position is significant in determining which AUG should serve as INITIATION site.

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