Which of the following about Rb tumor suppressor protein is correct?(a) It binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received(b) It is activated when phosphorylated by Cdk(c) It is a transcription factor(d) When a mitogenic signal is received, it binds the transcription factor E2F and thus stimulates the cell to enter S phaseThis question was addressed to me in examination.Origin of the question is Oncogenes, Tumor Suppressor Genes and Programmed Cell Death in division Biosignalling of Biochemistry

Which of the following about Rb tumor suppressor protein is correct?(a

1.	Which of the following about Rb tumor suppressor protein is correct?(a) It binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received(b) It is activated when phosphorylated by Cdk(c) It is a transcription factor(d) When a mitogenic signal is received, it binds the transcription factor E2F and thus stimulates the cell to enter S phaseThis question was addressed to me in examination.Origin of the question is Oncogenes, Tumor Suppressor Genes and Programmed Cell Death in division Biosignalling of Biochemistry
Answer» Right option is (a) It binds E2F transcription factor and PREVENTS cell from ENTERING S phase until a mitogenic signal is received To explain I would SAY: RB protein binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received.

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