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Which of the following acts as a GAP during translation?(a) eIF2B(b) eIF4F(c) eIF1a(d) eIF5BI had been asked this question during an online interview.This is a very interesting question from Control of Translation topic in division Gene Expression : Translation of Cytogenetics

Answer»

Right option is (d) eIF5B

Easiest explanation: While the eIF2B has a GEF activity, the eIF5 PROMOTES the phosphatase activity of eIF5B. This HELPS the GTP to hydrolysis to GDP thus helping in dissociation of tRNAi and initiation of TRANSLATION.



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