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Which of the following disease is caused by a chromosomal translocation?(a) Chronic myelogenous leukemia(b) Hodgkin’s B-cell lymphoma(c) Alzheimer’s disease(d) Parkinson’s diseaseThis question was posed to me in an online quiz.This intriguing question comes from Combating Cancer topic in division Cancer of Cell Biology

Answer»

Right ANSWER is (a) Chronic myelogenous leukemia

For explanation: Chronic myelogenous leukemia is caused by a chromosomal translocation that BRINGS together the proto-oncogene (ABL) in CONTACT with another GENE (BCR) to FORM a chimeric gene (BCR ABL).



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