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Which of the following is done by HCR?(a) Phosphorylation of eIF4E-BP(b) Phosphorylation of eIF2-alpha(c) Dephosphorylation of eIF4E-BP(d) Dephosphorylation of eIF2-AlphaThe question was posed to me in my homework.My question is based upon Initiation in portion Gene Expression : Translation of Cytogenetics

Answer»

Correct option is (b) Phosphorylation of eIF2-alpha

The best explanation: HCR is HEME CONTROLLED Repressor protein which SENSES the lack of heme in the medium and phosphorylated eIF2-alpha. This prevents the GEF activity of eIF2B and prevents translation. This measure prevents the waste of resources.



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