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Which of the following is topical with high concentration?(a) Lignocaine(b) Cocaine(c) Procaine(d) BenzocaineThis question was addressed to me in quiz.I'm obligated to ask this question of Mechanism of Action of Local Anesthetic topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology |
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Answer» RIGHT choice is (d) Benzocaine Best explanation: Used mainly as TOPICAL, due to its poor water solubility, and because of its low TOXICITY, it can be used in concentration up to 20%. Hydrolysed rapidly by plasma esterase to p-aminobenzoic ACID accounting for its low toxicity. Lignocaine is an amide-type drug. It is highly lipophilic and rapidly absorbed. |
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