Which of the following order of inducing cardiac arrhythmias of inhaled anesthetics is correct?(a) F Cl > Br > I(d) Br < I < F < ClThis question was addressed to me in final exam.My doubt stems from Mechanism of Action of General Anesthetics topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Which of the following order of inducing cardiac arrhythmias of inhale

1.	Which of the following order of inducing cardiac arrhythmias of inhaled anesthetics is correct?(a) F < Br < I < Cl(b) F < Cl < Br < I(c) F > Cl > Br > I(d) Br < I < F < ClThis question was addressed to me in final exam.My doubt stems from Mechanism of Action of General Anesthetics topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology
Answer» Right option is (b) F < CL < BR < I For explanation: Although halogenations of hydrocarbons and ethers increase anesthetic potency, it also increases the potential for INDUCING cardiac arrhythmias in the following order F < Cl < Br < I. Halogenated methyl ethyl ethers (ENFLURANE and Isoflurane) are more stable, are more potent, and have better clinical profile than halogenated diethyl ethers.

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