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Which of the following responsible for inflammatory response mainly?(a) COX 1(b) COX 2(c) COX 3(d) COX 4This question was posed to me in an interview.Asked question is from Drug Addiction and Abuse topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology |
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Answer» CORRECT choice is (b) COX 2 To elaborate: Cyclooxygenase-1 (COX-1) constitutively EXPRESSED in a WIDE variety of cells all over the body and thus known as “housekeeping enzyme” e.g.Gastric cytoprotection. Cyclooxygenase-2 (COX-2), inducible enzyme an immediate-early gene product in inflammatory and IMMUNE cells it is dramatically up-regulated during inflammation. |
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