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Which of the following takes place due to phosphorylation of isocitrate dehydrogenase?(a) Inhibits the binding of citrate at active site(b) Degrades the enzyme(c) Enhances the substrate-binding affinity(d) No reactionI got this question during an online interview.My question is from Regulatory Enzymes in chapter Enzymes, Carbohydrates and Gycobiology of Biochemistry

Answer» RIGHT option is (a) INHIBITS the BINDING of citrate at active site

For explanation I would say: The electrostatic repulsion by the PHOSPHORYL group inhibits the binding of citrate at active site.


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