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Which of these is not an NMD factor?(a) DCP1(b) Exonuclease(c) EJC(d) Ski 7This question was posed to me during an internship interview.My question is taken from Control of Translation topic in portion Gene Expression : Translation of Cytogenetics

Answer»

Right option is (B) Exonuclease

For explanation: NMD stands for nonsense mediated degradation which is responsible for degrading the MRNA prematurely when it has a nonsense MUTATION. Nonsense mutation can lead to a stop codon before the original stop codon. Here the only exonuclease also PARTICIPATES in normal turn over.



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