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Which of these mutations will have the least harmful effect?(a) Addition of 2 bases(b) Deletion of 3 bases(c) Transition of one base(d) Deletion of a chunkI got this question in homework.I'm obligated to ask this question of Genetic Code in division Gene Expression : Translation of Cytogenetics

Answer»

The correct choice is (c) Transition of one base

For explanation I would say: In all possibilities transition of a base would have least harmful effect as there are DEGENERATE CODONS for same amino acid. The NEW codon COULD thus be a silent mutation. Also if it is the 3rd base due to wooble HYPOTHESIS it will have negligible effect.



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