1.

Cyclin-CDK complex (here considering S cyclin) when active is responsible for phosphorylating several proteins and this often marks then for destruction by ubiquitination. What would be its effect on Cdt activity?(a) Activation(b) Inactivation(c) Destruction(d) Increased synthesisI have been asked this question in semester exam.My question is from DNA Replication Eukaryotes in division DNA Replication of Cytogenetics

Answer»

The CORRECT OPTION is (a) Activation

The best explanation: Cdt a PROTEIN necessary for initiation of replication is sequestered by geminin. S-cyclin-CDK phosphorylates and marks geminin for ubiquitination which makes Cdt free to EXPRESS its activity. However, it has no effect on Cdt CONCENTRATION or synthesis.



Discussion

No Comment Found

Related InterviewSolutions