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What is the fate of phosphorylated Cdc 6?(a) It is transported outside nucleus(b) It is ubiquitinylated(c) It gets activated(d) It forms a complex with CdtThis question was addressed to me in exam.I'd like to ask this question from DNA Replication Eukaryotes in division DNA Replication of Cytogenetics

Answer»

Correct choice is (B) It is ubiquitinylated

Explanation: Cdc 6 after triggering INITIATION dissociates from ORC and is phosphorylated to PREVENT re-initiation. It UNDERGOES UBIQUITINATION and destruction while MCM is phosphorylated and transported outside the nucleus. It ensures that Cdc 6 and MCM remain inactive and can’t re-initiate replication.



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