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What is the DNA composition of ARS?(a) A-T rich(b) G-C rich(c) Repeating A-T, G-C sequence(d) No specific sequence specialityThe question was posed to me at a job interview.Origin of the question is DNA Replication Eukaryotes in portion DNA Replication of Cytogenetics

Answer»

The CORRECT option is (a) A-T rich

Best explanation: A-T bases bound by 2 hydrogen bonds unlike G and C, which are bound by 3 hydrogen bonds. In such region DNA strand separation is easier as COMPARED to G-C rich regions. Hence, ARS which requires DNA melting to INITIATE replication is A-T rich.



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