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Deletion of which domain of ARS would give the least replication rate in eukaryotes?(a) A domain(b) B1 domain(c) B2 domain(d) B3 domainI got this question in unit test.I'd like to ask this question from DNA Replication Eukaryotes topic in chapter DNA Replication of Cytogenetics

Answer»

The CORRECT choice is (a) A domain

The BEST I can explain: The 11bp ‘A domain’ is the primary functional area of the ARS. Mutation in this domain GIVES 0% FUNCTIONALITY of ORC so lease replication. Other mutations also REDUCE replication rate but not to such extent.



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