To your cultured cell lines, you add growth factors like cytokines which act through MAPK cascade pathway. Which transition will it trigger?(a) S->G2(b) M->Anaphase(c) G1->S(d) G2->MThe question was posed to me in an internship interview.My doubt stems from DNA Replication Eukaryotes topic in portion DNA Replication of Cytogenetics

To your cultured cell lines, you add growth factors like cytokines whi

1.	To your cultured cell lines, you add growth factors like cytokines which act through MAPK cascade pathway. Which transition will it trigger?(a) S->G2(b) M->Anaphase(c) G1->S(d) G2->MThe question was posed to me in an internship interview.My doubt stems from DNA Replication Eukaryotes topic in portion DNA Replication of Cytogenetics
Answer» Correct answer is (c) G1->S To EXPLAIN I would say: ONE of the primary checkpoints to overcome incase of proliferation is G1 -> S check point. MAPK cascade leads to TRANSCRIPTION of genes required to INCREASE the CDK activity that leads to this transition. Once S phase is completed the cell must undergo mitosis although there is another CHECKPOINT before Anaphase.

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