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Which of the following catalyzes ADP-ribosylation of a diphthamide residue?(a) Chloramphenicol(b) Cycloheximide(c) Diphtheria toxin(d) RicinI had been asked this question in an international level competition.This interesting question is from Protein Synthesis topic in division DNA, RNA and Protein Metabolism of Biochemistry

Answer»

The correct OPTION is (c) Diphtheria TOXIN

For explanation I would say: Diphtheria toxin CATALYZES ADP-ribosylation of a diphthamide residue of EUKARYOTIC elongation factor eEF2, thereby inactivating it.



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