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101.	How is beta interferon produced?(a) Produced by virus-infected leukocytes(b) Produced by virus-infected fibroblasts(c) Produced by activated NK cells(d) Produced by bacterial activated leukocytesThe question was posed to me in unit test.The question is from Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology
Answer» Right choice is (b) Produced by virus-infected fibroblasts Explanation: Beta INTERFERON which is fibroblast interferon is produced by certain activated t Cells and NK cells. Interferons PLAY an important role in the first line of defense against viral infections. Interferons are part of the non-specific immune SYSTEM. Interferons are made by cells in response to an APPROPRIATE STIMULUS.

102.	How is alpha interferon produced?(a) Produced by virus-infected leukocytes(b) Produced by virus-infected fibroblasts(c) Produced by activated NK cells(d) Produced by bacterial activated leukocytesI got this question during a job interview.The question is from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology
Answer» The correct option is (a) Produced by virus-infected leukocytes The best EXPLANATION: INTERFERONS play an important ROLE in the first line of defense against viral infections. Interferons are made by cells in response to an appropriate stimulus. ALPHA interferon which is LEUKOCYTE interferon is produced by virus-infected leukocytes.

103.	Which of the following is not a symptom for Multiple sclerosis?(a) Constipation(b) Numbness(c) Twitching of eyes(d) PolydipsiaThis question was posed to me in an interview for job.I'd like to ask this question from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology
Answer» Right CHOICE is (d) Polydipsia Best explanation: Polydipsia is a SYMPTOM for diabetes which means meaning thirsty and drinking water frequently. Genitourinary symptoms of multiple sclerosis are constipation and urine FREQUENCY. Motor involving symptoms are muscle weakness, numbness. Visual symptoms of MS are blurring and twitching of eyes.

104.	The patient of Multiple sclerosis will start the remyelination process.(a) True(b) FalseThis question was posed to me during an online interview.The question is from Biopharmaceuticals topic in section Biopharmaceuticals of Drug Biotechnology
Answer» Correct CHOICE is (a) True The BEST explanation: Myelinating oligodendrocytes are able to rebuild thinner, less effective myelin sheaths.This may be reason symptoms decrease in TEMPORARILY DISAPPEAR during the early part of the disease. But there is still irreversible loss and nerve damage. It is the natural tendency of the NERVES to form myelin sheaths again.

105.	What is the problem with the blood-brain barrier of a patient of Multiple Sclerosis?(a) Springs a leak(b) Allows all T-cells(c) Allows all antigens(d) Becomes rigid even don’t let carbon dioxide pass through.This question was posed to me in exam.The doubt is from Biopharmaceuticals topic in division Biopharmaceuticals of Drug Biotechnology
Answer» Right answer is (a) Springs a leak To explain: Normally BBB prevents the passage of potentially harmful substances through blood vessel walls within the brain. But MS patients’ BBB ‘springs a leak’ thus it, as a RESULT, allows activated T-cell to cross BBB and mount an attack on myelin. This leads to SEVERAL EVENTS that LEAD to demyelination such as SWELLING, activation of macrophages, etc.

106.	APC cells present ______________ antigen to T cells.(a) Axon(b) Myelin(c) Actin(d) OligodendrocytesI have been asked this question during an interview.My question is taken from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology
Answer» Correct answer is (B) Myelin To elaborate: APC cells present myelin antigen to T-cells. These t cells PASS through the BBB. NORMALLY BBB prevents the passage of potentially harmful substances through blood vessel walls within the BRAIN. But MS patients’ BBB ‘springs a leak’ which tends to allow all the activated t cells across the BBB which attack the myelin sheath.

107.	Which of the following is not a key player in Multiple sclerosis?(a) Axon(b) Myelin(c) Actin(d) T cellsThis question was addressed to me in my homework.Asked question is from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology
Answer» The correct choice is (c) Actin The explanation is: Actin is present in muscles; it helps in muscles contraction and relaxation. Myelin gets ATTACKED by the immune SYSTEM. Oligodendrocytes, Blood vessels that supply OXYGEN and nutrients, cytokines, t-cells, antigen PRESENTING cells are the key players of MULTIPLE sclerosis.

108.	Chances in females are more than in men.(a) True(b) FalseThe question was asked in quiz.The doubt is from Biopharmaceuticals topic in portion Biopharmaceuticals of Drug Biotechnology
Answer» Correct answer is (a) True Easiest EXPLANATION: Genetic FACTORS which may control or influence MS is 2-3 times more LIKELY in females than MALES. This may be VARIABLE among races and ethnicities such that it is highest in northern European Caucasians, lowest in Asians. No particular gene has been identified so far likely multiple genes are involved.

109.	Which age group is more prone to Multiple sclerosis?(a) 0-5 years(b) 20-75 years(c) Adults of above 20 years(d) Adults of above 70 yearsI have been asked this question during an online interview.This interesting question is from Biopharmaceuticals topic in portion Biopharmaceuticals of Drug Biotechnology
Answer» Correct choice is (B) 20-75 years Explanation: AGE of diagnosis usually 20 to 50. Patients have been as young as 2 and as old as 75 years of age. The environment may be influencing MS. MULTIPLE sclerosis is predominant in cooler climates and areas further from the equator. Thus, researchers have the idea that VITAMIN D may play a role.

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