InterviewSolution
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InterviewSolution
This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Nuclear localization signal is rich in ____________(a) Tryptophan and histidine(b) Serine and threonine(c) Glutamine and asparagine(d) Lysine and arginineI got this question during an interview.I'd like to ask this question from Protein Targeting and Degradation in portion DNA, RNA and Protein Metabolism of Biochemistry |
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| 2. |
Which of the following statements regarding splicing in eukaryotes is correct?(a) Several reactions in the splicing process involve hydrolysis of ATP(b) Exons are spliced out and introns are retained in the mature mRNA transcript(c) Splicing takes place in the cytosol(d) Small nuclear RNAs are retained in the mature mRNA transcriptThis question was posed to me during an interview.My enquiry is from RNA Processing topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct answer is (a) Several reactions in the SPLICING process INVOLVE hydrolysis of ATP |
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| 3. |
Which of the following process generates a new copy of the transposable element at a new location of DNA?(a) Homologous genetic recombination(b) Site specific recombination(c) Non-homologous recombination(d) Replicative recombinationI have been asked this question by my college director while I was bunking the class.I would like to ask this question from DNA Recombination topic in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right CHOICE is (d) Replicative RECOMBINATION |
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| 4. |
Which of the following involves remarkable capacity of a short segment of DNA to move from one place to another?(a) DNA transposition(b) DNA replication(c) Translation(d) TranscriptionThe question was asked during a job interview.I would like to ask this question from DNA Recombination topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct answer is (a) DNA transposition |
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| 5. |
Which of the following catalyzes ADP-ribosylation of a diphthamide residue?(a) Chloramphenicol(b) Cycloheximide(c) Diphtheria toxin(d) RicinI had been asked this question in an international level competition.This interesting question is from Protein Synthesis topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct OPTION is (c) Diphtheria TOXIN |
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| 6. |
A codon contains how many nucleotides?(a) 1(b) 2(c) 3(d) 4I had been asked this question during an internship interview.Question is taken from The Genetic Code topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct choice is (c) 3 |
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| 7. |
Which of the following is an incorrect statement about m-RNA?(a) Cap is added to the 5’ end(b) Introns are removed and exons are spliced together(c) Histone mRNAs lack 5’ cap(d) Poly-A tail is added to the 3’ endI got this question during an internship interview.This key question is from RNA Processing topic in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right option is (b) Introns are removed and EXONS are SPLICED together |
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| 8. |
Binding of the prokaryotic DNA dependent RNA polymerase to promoter site is inhibited by ____________(a) Rifampicin(b) Tetracycline(c) Puromycin(d) StreptomycinThis question was posed to me in exam.I'd like to ask this question from DNA-Dependent Synthesis of RNA in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right option is (a) RIFAMPICIN |
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| 9. |
Which of the following enzymes remove supercoiling in replicating DNA ahead of the replication fork?(a) DNA polymerases(b) Helicases(c) Primases(d) TopoisomerasesThis question was addressed to me by my school principal while I was bunking the class.Question is from DNA Replication in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct answer is (d) TOPOISOMERASES |
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| 10. |
Recombinational repair is often due to ____________(a) Incorporation of many incorrect nucleotides by DNA pol(b) Many cystidine dimer and associated large gaps in a strand(c) Many thymidine dimer formations and associated large gaps in a strand(d) All of the mentionedI have been asked this question during an interview.Asked question is from DNA Repair topic in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» CORRECT option is (c) Many thymidine DIMER formations and associated large GAPS in a strand Explanation: RECOMBINATIONAL repair is OFTEN due to many thymidine dimer formations and associated large gaps in a strand. |
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| 11. |
Eukaryotes differ from prokaryote in mechanism of DNA replication due to ____________(a) Use of DNA primer rather than RNA primer(b) Different enzyme for synthesis of lagging and leading strand(c) Discontinuous rather than semi-discontinuous replication(d) Unidirectional rather than semi-discontinuous replicationI have been asked this question in exam.The doubt is from DNA Replication topic in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right option is (c) Discontinuous RATHER than semi-discontinuous replication |
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| 12. |
Which of the following inactivates the 60S subunit of eukaryotic ribosomes?(a) Chloramphenicol(b) Cycloheximide(c) Diphtheria toxin(d) RicinI have been asked this question by my college director while I was bunking the class.This intriguing question originated from Protein Synthesis in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct CHOICE is (d) Ricin |
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| 13. |
Which of the following introns have self-splicing activity?(a) Group I and group II(b) Group II and group III(c) Group III and group IV(d) Group I and group IIII had been asked this question by my school principal while I was bunking the class.This intriguing question comes from RNA-Dependent Synthesis of RNA and DNA in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» RIGHT answer is (a) GROUP I and group II Best explanation: Only group I and group II introns have self-splicing ACTIVITY. |
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| 14. |
Which of the following promotes branch migration at higher rates than does Rec-A?(a) Rec-B(b) Rec-C(c) Rec-D(d) Ruv-A and Ruv-BThis question was posed to me by my school principal while I was bunking the class.Question is from DNA Recombination in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct answer is (d) Ruv-A and Ruv-B |
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| 15. |
The enzyme photolyase is used in what method of repair?(a) Base excision(b) Photo reactivation(c) Nucleotide excision(d) None of the mentionedThis question was addressed to me in my homework.My question is taken from DNA Repair in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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| 16. |
Which of the following has the self-repairing mechanisms?(a) DNA and RNA(b) DNA, RNA and protein(c) Only DNA(d) DNA and proteinsThis question was posed to me in an internship interview.The doubt is from DNA Repair in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» CORRECT choice is (c) Only DNA The EXPLANATION: Only DNA has a self-repairing mechanism. |
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| 17. |
Proteins tagged with mannose 6-phosphate are transported to ____________(a) Golgi complex(b) Mitochondria(c) Lysosome(d) NucleusThe question was asked by my college professor while I was bunking the class.My question is from Protein Targeting and Degradation topic in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct answer is (c) Lysosome |
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| 18. |
The termination codon is not ____________(a) AUG(b) UAA(c) UAG(d) UGAThe question was asked during an interview for a job.The above asked question is from The Genetic Code in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» CORRECT choice is (a) AUG Easy EXPLANATION: AUG is an INITIATION CODON. |
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| 19. |
Which type of splicing reaction requires a guanine nucleoside or nucleotide cofactor that is not used as a source of energy?(a) Spliceosomal(b) Group I(c) Group II(d) Group IVThe question was asked in my homework.This interesting question is from RNA Processing in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct answer is (B) GROUP I |
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| 20. |
Which of the following is called a resolvase?(a) Ruv-C(b) Ruv-A(c) Ruv-B(d) Rec-AI have been asked this question in an interview.My question is based upon DNA Recombination in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct ANSWER is (a) Ruv-C |
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| 21. |
What is the role of mRNA in protein synthesis?(a) It translates genetic code to a specific amino acid(b) It modifies mRNA molecules prior to protein synthesis(c) It provides a genetic blueprint for the protein(d) It catalyzes the processI had been asked this question during an internship interview.My question comes from Protein Synthesis topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct choice is (C) It provides a genetic blueprint for the protein |
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| 22. |
In how many steps protein biosynthesis takes place?(a) 2(b) 3(c) 4(d) 5I have been asked this question in an internship interview.My question is taken from Protein Synthesis topic in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The CORRECT choice is (d) 5 |
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| 23. |
Which of the following statements about viruses is true?(a) They contain DNA(b) They contain RNA(c) They contain protein(d) They are susceptible to lipid solventsThe question was posed to me in an internship interview.Origin of the question is RNA-Dependent Synthesis of RNA and DNA topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct answer is (c) They contain protein |
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| 24. |
HIV may not respond to ____________(a) Nucleoside analogues(b) Protease inhibitors(c) Neuraminidase inhibitors(d) Reverse transcriptase inhibitorsI had been asked this question in an interview for internship.This intriguing question comes from RNA-Dependent Synthesis of RNA and DNA in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct CHOICE is (c) Neuraminidase inhibitors |
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| 25. |
TBP stands for?(a) TATA box polymerase(b) TATA-box binding protein(c) Transcription associated factor(d) Transcription factor binding proteinThe question was asked in a national level competition.My query is from DNA-Dependent Synthesis of RNA topic in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct OPTION is (B) TATA-box binding PROTEIN |
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| 26. |
Which enzyme used to join bits of DNA?(a) DNA polymerase(b) DNA ligase(c) Endonuclease(d) PrimaseI got this question in homework.I'd like to ask this question from DNA Replication in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct option is (b) DNA LIGASE |
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| 27. |
Which of the following enzymes is the principal replication enzyme in E. coli?(a) DNA polymerase I(b) DNA polymerase II(c) DNA polymerase III(d) None of the mentionedThis question was addressed to me in a national level competition.I'm obligated to ask this question of DNA Replication topic in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct option is (c) DNA POLYMERASE III |
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| 28. |
Secretory proteins are synthesized by ____________(a) Ribosomes on the nuclear membrane(b) Ribosomes on endoplasmic reticulum(c) Free ribosomes(d) None of the mentionedThe question was asked during a job interview.My question comes from Protein Targeting and Degradation in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct option is (B) RIBOSOMES on ENDOPLASMIC reticulum |
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| 29. |
Which of the following blocks the peptidyl transferase of 80S eukaryotic ribosomes?(a) Chloramphenicol(b) Cycloheximide(c) Diphtheria toxin(d) RicinThis question was posed to me during an internship interview.I would like to ask this question from Protein Synthesis in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» RIGHT ANSWER is (b) Cycloheximide Explanation: CHLORAMPHENICOL does not affect CYTOSOLIC protein synthesis in eukaryotes. |
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| 30. |
Which is the third elongation step in bacteria?(a) Peptide bond formation(b) Binding of an incoming aminoacyl t-RNA(c) Translocation(d) None of the mentionedThe question was asked in unit test.The query is from Protein Synthesis in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct option is (C) Translocation |
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| 31. |
Which one of the following best describes the cap modification of eukaryotic mRNA?(a) Modified guanine nucleotide added to the 3’ end of the transcript(b) Modified guanine nucleotide added to the 5’ end of the transcript(c) String of adenine nucleotides added to the 3’ end of the transcript(d) String of adenine nucleotides added to the 5’ end of the transcriptThis question was addressed to me in an internship interview.The query is from RNA Processing topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct option is (B) Modified guanine nucleotide ADDED to the 5’ end of the transcript |
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| 32. |
What is the function of enzyme involved in base excision repair?(a) Addition of correct base(b) Addition of correct nucleotide(c) Removal of incorrect base(d) Removal of phosphodiester bondI have been asked this question in an interview.Origin of the question is DNA Repair topic in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right answer is (C) REMOVAL of incorrect base |
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| 33. |
70S prokaryotic ribosome is the complex of ____________(a) 30S + 50S(b) 30S + 40S(c) 20S + 60S(d) 20S + 30SThe question was asked in examination.Question is from RNA Processing topic in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right option is (a) 30S + 50S |
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| 34. |
DNA unwinding is done by ____________(a) Ligase(b) Helicase(c) Topoisomerase(d) HexonucleaseI had been asked this question in semester exam.This interesting question is from DNA Replication topic in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» RIGHT answer is (b) Helicase To explain I would say: These enzymes move along the DNA and SEPARATE the strands using CHEMICAL ENERGY from ATP. |
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| 35. |
Signal sequences are ____________(a) Short peptide sequences attached to a protein that initiates its degradation by digestive enzymes(b) Short peptide sequences to transport a protein to the nucleus(c) Glycoproteins that serve as an address for transporting newly synthesized protein to the correct location(d) Short peptide sequences that serve as an address for transporting newly synthesized proteins to the correct locationThis question was posed to me in an interview for internship.Query is from Protein Targeting and Degradation topic in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct OPTION is (d) SHORT peptide sequences that serve as an address for TRANSPORTING newly synthesized proteins to the correct location |
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| 36. |
Which of the following solves the problem of shortening of chromosomes in each cell cycle?(a) DNA ligase(b) Endonuclease(c) Telomerase(d) RNA polymeraseI got this question by my school teacher while I was bunking the class.This intriguing question comes from RNA-Dependent Synthesis of RNA and DNA in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct choice is (c) Telomerase |
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| 37. |
The largest class of introns which are found in nuclear mRNA primary transcript is?(a) Spliceosomal introns(b) Group I introns(c) Group II introns(d) Group IV intronsThe question was posed to me in a national level competition.Asked question is from RNA Processing in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» CORRECT option is (a) Spliceosomal introns For EXPLANATION I WOULD SAY: Spliceosomal introns are the LARGEST class of introns which are found in nuclear mRNA primary transcript. |
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| 38. |
What is the main function of t-RNA?(a) Proof reading(b) Inhibits protein synthesis(c) Identifies amino acids and transport them to ribosomes(d) None of the mentionedThe question was asked at a job interview.The doubt is from RNA Processing in section DNA, RNA and Protein Metabolism of Biochemistry |
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| 39. |
Which is the correct order of transport of protein in a secretory pathway?(a) Protein synthesized in the cytoplasm-SER lumen-RER lumen-cis Golgi-median Golgi-trans Golgi-vesicles-fusion of vesicles with plasma membrane-exocytosis(b) Protein synthesized in the cytoplasm-RER lumen-cis Golgi-median Golgi-trans Golgi-vesicles-fusion of vesicles with plasma membrane-exocytosis(c) Protein synthesized in the cytoplasm- vesicles -SER lumen-RER lumen-cis Golgi-median Golgi-trans Golgi-fusion of vesicles with plasma membrane-exocytosis(d) Protein synthesized in the cytoplasm- RER lumen-trans Golgi -median Golgi-cis Golgi -vesicles-fusion of vesicles with plasma membrane-exocytosisThis question was posed to me in class test.I'd like to ask this question from Protein Targeting and Degradation in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» CORRECT OPTION is (B) Protein synthesized in the cytoplasm-RER lumen-cis Golgi-median Golgi-trans Golgi-VESICLES-fusion of vesicles with plasma membrane-exocytosis The explanation is: Protein synthesized in the cytoplasm-RER lumen-cis Golgi-median Golgi-trans Golgi-vesicles-fusion of vesicles with plasma membrane-exocytosis. |
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| 40. |
Posttranslational modification of many eukaryotic proteins begins in the ____________(a) Endoplasmic reticulum(b) Mitochondria(c) Chloroplasts(d) NucleusThe question was posed to me in final exam.This key question is from Protein Targeting and Degradation in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» RIGHT OPTION is (a) Endoplasmic reticulum To explain: Most LYSOSOMAL, membrane or SECRETED proteins have an amino-terminal signal sequence that marks them for translocation into the lumen of the ER. |
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| 41. |
In which of the following cases the first base of anticodon pairs with two codons?(a) When the first base of anticodon is A or C(b) When the first base of anticodon is A or G(c) When the first base of anticodon is inosine(d) When the first base of anticodon is G or UThe question was asked in class test.This interesting question is from The Genetic Code topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The CORRECT option is (d) When the first BASE of anticodon is G or U |
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| 42. |
The eukaryotic mRNA binding to the ribosomes is facilitated by ____________(a) T-RNA(b) Poly-A tail(c) Shine Dalgarno sequence(d) 7-methyl guanosine capThe question was asked by my college director while I was bunking the class.Question is taken from Protein Synthesis in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» CORRECT OPTION is (d) 7-methyl guanosine cap For explanation: The initiating (5’) AUG is guided to its correct position by the SHINE Dalgarno sequence in the mRNA. |
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| 43. |
Which enzyme used in the formation of cDNA from mRNA?(a) Polymerase(b) Helicase(c) Reverse transcriptase(d) GyraseThe question was asked during an online interview.I want to ask this question from RNA-Dependent Synthesis of RNA and DNA in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right option is (c) Reverse transcriptase |
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| 44. |
Reverse transcriptase does not catalyze ____________(a) RNA-dependent DNA synthesis(b) RNA degradation(c) DNA-dependent DNA synthesis(d) DNA-dependent RNA synthesisI have been asked this question in an international level competition.The origin of the question is RNA-Dependent Synthesis of RNA and DNA topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct option is (d) DNA-dependent RNA synthesis |
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| 45. |
The DNA polymerase involved in base excision repair is ____________(a) DNA polymerase α(b) DNA polymerase β(c) DNA polymerase σ(d) DNA polymerase γThis question was addressed to me in homework.Question is from DNA Repair topic in portion DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct OPTION is (B) DNA polymerase β |
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| 46. |
80S eukaryotic ribosome is the complex of ____________(a) 60S and 40S(b) 40S and 20S(c) 60S and 50S(d) 30S and 20SThe question was posed to me during an interview.This is a very interesting question from RNA Processing topic in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right answer is (a) 60S and 40S |
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| 47. |
Number of hydrogen bonds that form between U and A in a Watson-Crick base pair interactions?(a) 0(b) 1(c) 2(d) 3This question was addressed to me in a national level competition.I'd like to ask this question from DNA-Dependent Synthesis of RNA in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Correct option is (c) 2 |
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| 48. |
Which of the following is not involved in the post transcriptional processing of t-RNA?(a) Base modulation(b) Attachment of CCA arm(c) Splicing(d) Attachment of poly-A tailThe question was asked in final exam.I'd like to ask this question from RNA Processing in division DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right ANSWER is (d) Attachment of poly-A tail |
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| 49. |
Where does RNA polymerase bind DNA?(a) Promoter(b) Operator(c) Enhancer(d) None of the mentionedI got this question in an interview.This interesting question is from DNA-Dependent Synthesis of RNA topic in section DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» The correct option is (a) Promoter |
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| 50. |
Which of the following is true about DNA polymerase?(a) It can synthesize DNA in the 5’ to 3’ direction(b) It can synthesize DNA in the 3’ to 5’ direction(c) It can synthesize mRNA in the 3’ to 5’ direction(d) It can synthesize mRNA in the 5’ to 3’ directionThis question was posed to me in an interview.This interesting question is from DNA Replication in chapter DNA, RNA and Protein Metabolism of Biochemistry |
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Answer» Right ANSWER is (a) It can SYNTHESIZE DNA in the 5’ to 3’ direction |
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