InterviewSolution

Explore topic-wise InterviewSolutions in .

This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.

51.	What is the equation for bioavailability?(a) [AUC]std Dstd τtest / [AUC]test Dtest τstd(b) [AUC]test Dtest τstd / [AUC]std Dstd τtest(c) [AUC]test Dstd τtest / [AUC]std Dtest τstd(d) 1 / [AUC]std Dtest τstdThis question was posed to me by my college director while I was bunking the class.My question is based upon Bioavailability topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Correct answer is (c) [AUC]TEST Dstd τtest / [AUC]std Dtest τstd To EXPLAIN I would say: The equation of bioavailability is [AUC]test Dstd τtest / [AUC]std Dtest τstd, D stands for dose ADMINISTERED, test and std indicate the test and standard DOSES of the same drug to determine the relative availability. The dosing INTERVAL is τ.

52.	Multiple dose study is better since we can understand the peak, valley, drug blood levels, etc.(a) True(b) FalseI had been asked this question in a national level competition.My doubt is from Bioavailability in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» The correct ANSWER is (a) True For explanation: MULTIPLE dose study is difficult to control since it exposes the SUBJECT to a higher level of drug which is dangerous sometimes. This method is very tedious and time-consuming. The advantages of such method are ACCURATELY reflected how the drug should be used, easy to predict peak and valley of a drug, can be ethically performed on the PATIENT, better evaluation of the performance of controlled release formulation is possible.

53.	What is bioavailability?(a) The time of absorption of the drug from its dosage form(b) The rate of absorption of the unchanged drug from its dosage form(c) The time of absorption of the unchanged drug from its dosage form(d) The rate of absorption of the drug from its dosage formI have been asked this question in a job interview.I would like to ask this question from Bioavailability topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Right option is (b) The rate of absorption of the unchanged DRUG from its dosage FORM To explain: Physiologic availability, biologic availability or just bioavailability is defined as the rate or the amount of absorption of an unchanged drug from its dosage form. The rate with which the drug is GETTING absorbed is important since in some treatment such as ASTHMA attack rapid onset action is REQUIRED.

54.	In the given picture, which kinetic order the graph is following at the marked place?(a) 1st order kinetics(b) 2nd order kinetics(c) Mixed order kinetics(d) Zero-order rateI got this question in unit test.The above asked question is from Non Linearity of Drugs topic in portion Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Right choice is (d) Zero-order RATE Explanation: The plot is of Michaelis-Menten EQUATION –dC/dt = Vmax C/Km+C, Initially the rate INCREASES linearly with CONCENTRATION thus showing first order kinetics. At lower doses, it follows 1st order kinetics. It becomes mixed order at intermediate doses and then reaches maximum Vmax. Beyond this, it proceeds at a constant rate thus following zero order kinetics.

55.	Which organ comprises the peripheral compartment in a two compartment model?(a) Liver(b) Lungs(c) Kidneys(d) MusclesThis question was addressed to me during an interview.I need to ask this question from One & Two Compartment Open Model in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Right choice is (d) MUSCLES For explanation: The PERIPHERAL compartment or compartment 2 in a two compartment model comprises of POORLY perfused and slowly equilibrating tissues such as muscles, skin, adipose tissue, etc. These are considered as a HYBRID of several functional physiologic units.

56.	To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?(a) 1080 ml(b) 1080 g(c) 1080 mg(d) 1g/mlThe question was posed to me by my school teacher while I was bunking the class.Asked question is from One & Two Compartment Open Model topic in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Correct answer is (C) 1080 mg Easy explanation: The apparent VOLUME of distribution VD is given by Amount of drug in the body (X) / plasma drug CONCENTRATION (C). Vd is expressed in liters or ml. to find out the amount of drug, the EQUATION is the apparent volume of distribution (Vd)*plasma drug concentration (C).

57.	In the given picture, which kinetic order the graph is following at the marked place?(a) 1st order kinetics(b) 2nd order kinetics(c) Mixed order kinetics(d) 1st order at higher dosesThe question was asked in homework.This interesting question is from Non Linearity of Drugs in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Right OPTION is (a) 1ST order kinetics For explanation I would say: The plot is of Michaelis-Menten equation –dC/dt = Vmax C/Km+C, Initially the rate increases linearly with concentration THUS showing first order kinetics. At lower doses, it follows 1st order kinetics. It becomes MIXED order at higher concentration and then REACHES maximum Vmax. Beyond this, it proceeds at a constant rate thus following zero order kinetics.

58.	What is the equation to find out the apparent volume of distribution?(a) Amount of drug in the body/plasma drug concentration(b) Plasma drug concentration/amount of drug in the body(c) 1 / plasma drug concentration(d) 1 / Amount of drug in the bodyThe question was asked during a job interview.The query is from One & Two Compartment Open Model in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer»

59.	How much time does an intravenously administered drug take to complete a complete circulation?(a) 5-8 min(b) 7-10 min(c) 1-3 min(d) 1 minThis question was addressed to me in homework.My enquiry is from One & Two Compartment Open Model topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» Correct ANSWER is (c) 1-3 min To EXPLAIN: When any drug is ADMINISTERED intravenously, it takes 1-3min for a COMPLETE circulation of the whole body. Thus the rate of absorption is not taken into ACCOUNT when any drug is administered intravenously.